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On the supportive side, the foundational cell-culture work reported that the distinct E-domain of MGF inhibits terminal differentiation of myoblasts while increasing their proliferation a behavior opposite to that of mature IGF-1, and one that would fit the proposed role of expanding the precursor pool before differentiation

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10.1016/bs.pmbts.2016.05.007 Progress in Molecular Biology and Translational Science 45 WiltonM.Charron-MazenodL.MooreR.LewenzaS