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If the BMI has dropped below the payer threshold during treatment, continued coverage may require additional documentation showing that discontinuation would likely result in weight regain

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(6.1) The most common adverse reactions (incidence 20%) of pemetrexed when administered in combination with pembrolizumab and platinum chemotherapy are fatigue/asthenia, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, dyspnea, and pyrexia

Some researchers have also proposed that cleared FTPP might compete with creatinine for transport systems in the proximal tubule, which would explain the creatinine elevation without true glomerular damage