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These polyunsaturates are highly subject to peroxidation, either spontaneously or enzymatically by cyclooxygenases and lipoxygenases, because their unsaturated (double bonded) carbons are un conjugated, i.e., separated by an interposed, singly bonded carbon, classified as alpha methylenic because its C-H bonds are activated due to the distribution of bonding electrons over a "spread" of four to five carbons

Methods: MUP-uPA mice (MUP mice) were used as the NASH model, and a conditional KrasG12D model (KC mice: LSL-Kras G12D/+ ;PDX-1-Cre ) was used as the pancreatic Kras mutation model

Rather, it's far more beneficial to figure out the lowest effective dose for you in a given context

PMID: 21718053