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These symptoms include increased hyperalgesia (Sun et al., 2016), increased fear learning (Perrine et al., 2016), reduced fear extinction (Lin et al., 2016a), increased arousal (Serova et al., 2013), depression and anhedonia (Enman et al., 2015

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The possible onset and intensity of local adverse reactions (such as seborrhea or dandruff formation) were analyzed by using a nano-parametric scale from 0 to 3