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Preoperative oral administration of L-theanine and cystine regulates the oxidation-reduction cycle of GSH, decreases the inflammatory cytokines, alleviates the infiltration of white blood cells, and reduces the damage of inflammatory injury to the body tissues, thus improving the survival rate after intestinal ischemia-reperfusion in a dose-dependent manner [32]

Ponesimod protects against neuronal death by suppressing the activation of A1 astrocytes in early brain injury after experimental subarachnoid hemorrhage

The idea was further validated by inhibiting glutathione synthesis by BSO where Sp administration caused GSH to increase by ~1.5 fold with concomitant reduction in GSSG (Fig

It also activates the Nrf2 pathway, which upregulates antioxidant enzymes like CAT, SOD2, and HO-1, strengthening the cellular response to oxidative stress 197,199