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doi: 10.1093/jn/130.5.1471S

Notch Pathway Activation Targets AML-Initiating Cell Homeostasis and Differentiation

On the one side, p53 promotes the expression of SAT1 (Qiu et al., 2020), and then increased SAT1 cooperates with ROS to lead to lipid peroxidation (Murphy 2016), further oxidizes PUFAs, and finally causes ferroptosis