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Recent studies have revealed that gut microbiota alterations, mucosal inflammation, and intestinal permeability were associated with metabolic disorders in PACS

Furthermore, a recent study demonstrated that oxaliplatin inhibited prolyl hydroxylase, an enzyme that hydroxylates proline in the N-terminal ankyrin repeat of TRPA1, which leads to the enhanced sensitivity of TRPA1 (Miyake et al., 2016)