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2C), indicating that PQS-induced elevated cellular free iron is a result of extracellular uptake from the RPMI1640 + FBS medium

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however, because of the relatively small number of patients treated, the lack of long-term follow-up data on large numbers of patients, and the potential for serious AEs (e.g., immunosuppression, nephrotoxicity), the Panel judged some uncertainty remains in the balance between benefits and risks/burdens