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doi: 10.1016/j.intimp.2016.08.006 8 LiBLiuGLiuRHeSLiXHuangLet al

Also, doses higher than recommended will not increase efficacy but will increase the risk of developing serious adverse events

104 These indicate that cAMP is regulated via PDEs, and two direct downstream effectors of cAMP (PKA and Epac)

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