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Among various drug resistance factors, the TME plays a significant role in the host response to immunotherapy 200

There are high levels of ketone-metabolizing enzymes in the brain and their capacities for taking up ketone bodies are higher in infancy than in adulthood 18,21

NADPH oxidase is dormant in resting cells, but becomes activated by inflammatory cytokines and environmental pollutants

In this work, we used a combination of biophysical techniques and cryo-electron microscopy (Cryo-EM), showing that human CBS full-length protein polymerises as a filament adopting two very different morphologies dependent on SAM binding and that polymerisation plays a role in both enzyme activation and stability