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Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicants

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Zhao, J., Luo, D., Liang, Z., Lao, L., & Rong, J

Human hepatic microsomal cytochrome P450 enzymes metabolize 4-OH-TAM and 3-OH-TAM to produce the further oxidized metabolite, 3,4-dihydroxytamoxifen (3,4-diOH-TAM) 7,8