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346 However, the complex is cleaved in the injured kidney by proteases including plasmin, MMP2 and MMP9, and thrombospondin to release active TGF-1

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Studies on developing rats have also shown that melatonin can alleviate spatial learning and memory impairments by suppressing isoflurane-induced endoplasmic reticulum stress through the Sirtuin 1/Mitofusin 2/Protein kinase RNA-like endoplasmic reticulum kinase signaling pathway [218]