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Pajares M, Rojo AI, Arias E et al (2018) Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A

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administered thiamine over several days and observed improved lactate clearance, particularly among patients with baseline thiamine deficiency 59

Moderate HO-1 activation stabilizes plaques via antioxidative effects, whereas high HO-1 expression promotes macrophage ferroptosis, matrix metalloproteinase activity, and M0 macrophage infiltration, resulting in fibrous cap thinning and plaque instability (86)