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doi: 10.1016/j.ajme.2017.09.001 82 WangYBranickyRNoAHekimiS

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MitoTEMPO, a mitochondrial antioxidant, can directly target mitochondria through the targeted design of antioxidants and related carriers, and can be rapidly transformed into a ubiquinol form with strong antioxidant activity, effectively eliminating ROS and suppressing oxidative stress ( SS-31 is a mitochondria-targeted peptide that selectively localizes to the inner mitochondrial membrane and reduces mtROS accumulation in a dose-dependent manner (Zhao et al., 2004)