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nhr-49 is essential to achieve longevity in several dietary and genetic models of DR (Figure 2)

Activation of nuclear factor-kappaB in cultured endothelial cells by increased glucose concentration: prevention by calphostin C J Cardiovasc Pharmacol 1997 30 : 528532 Shoji S, Furuishi K, Ogata A, Yamataka K, Tachibana K, Mukai R, Uda A, Harano K, Matsushita S, Misumi S

Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: Role of microenvironment of immune system organs and neuroendocrine factors