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We next interrogated the gene expression levels of Insr and Igf1r on CD4 + T helper cell subsets (Th1, Th2, Th17, Treg), which we generated in vitro by activating splenic CD4 + T cells in the presence of cytokines and antibodies that promote subset differentiation, as previously described 29

In some embodiments, the invention encompasses cations of Formula I, wherein: R 1 is C 1-4 alkyl

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