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Upregulated autophagosome biogenesis might be protective in the early stages of diseases such as AD (as suggested by mouse studies 270 ), but may be ineffective or compound the lysosome failure that becomes overt at later stages

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Population Doubling Level Calculation To calculate the PDL, a formula was used as follows: n = 3.32 (log UCY log I ) + X , where n is the final PDL at the end of a given subculture, UCY is the cell yield at that point, I is the cell number used as inoculum to begin that subculture, and X is the PDL of the inoculum used to initiate the subculture being quantitated (Pham et al., 2020)

Eur J Case Rep Intern Med 7(2):001394