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In a murine model, chitosan-coated SeNPs were 10-fold less toxic than aqueous selenite, with a 50% mortality rate for 24 mg selenite/g of body mass compared to 250 mg/g of body mass for chitosan-SeNPs [42]

TABLE 2 Application of zebrafish inflammation models in studying the anti-inflammatory mechanisms of plant compounds

Although aldosterone-induced oxidative or nitrative stress quickly stimulated antioxidant or detoxifying enzymes such SOD, thioredoxin (TRX), HO-1, or GCSc, this adaptive survival response appeared to be fleeting and overpowered by a chronic increased generation of ROS/RNS