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While free PUFAs can be oxidized, their oxidation products are efficiently cleared by antioxidant systems and do not compromise membrane integrity

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To identify the transcriptional adaptations underlying the metabolic changes induced by GSH depletion, we performed qRT-PCR to quantify the expression of key regulators of lipid and glucose metabolism, as well as fibrosis, in liver tissues from mice fed either a chow diet or HFD