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Estriol has little estrogen agonist activity for the same reason [4, 15]

Blood 114(22):344-45, 2009

In preclinical studies, NTZ suppresses intracellular M.tb proliferation by inhibiting the enzymatic activity of human quinone oxidoreductase (NQO1), which in turn inhibits the mTORC1 pathway and induces autophagy [19]