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Table 1 Drugs used in RA treatment that act by regulating ROS or the mitochondria

By integrating research findings from PCC and ME/CFS, we seek to construct a pathophysiological framework that may account for multi-system interactions, potentially providing a more comprehensive understanding of the onset and progression of PEM

Safety and Clinical Considerations Methylene Blue is contraindicated in certain populations, including: Individuals on SSRIs or serotonergic medications (risk of serotonin syndrome) Patients with G6PD deficiency Certain cardiovascular conditions This is why medical screening is essential