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ICI therapies disrupt the sensing of inhibitory receptor signals delivered from the transformed tissue by tumor-specific T or NK cells to reinvigorate their cytotoxic capacity ( In spite of the apparent effectiveness of ICI-based immunotherapies, they often work only in a subset of patients ( 2 Materials and methods 2.1 Ethics approval and consent to participate Fresh blood samples were obtained from healthy volunteers and patients in accordance to the Helsinki declaration

Elevated fumarate levels have also been linked to mitochondrial metabolic rewiring in aggressive high-grade prostate cancer [63]

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