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reported that CB-839 could promote the production of reactive oxygen species (ROS) in colorectal cancer cells, cause nuclear translocation of Nrf2, and subsequently upregulate the expression of uridine phosphorylase 1 (UPP1), which promotes the activation of 5-fluorouracil (5-FU)

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Metformin commonly causes gastrointestinal side effects, nausea, diarrhoea, and abdominal discomfort, particularly during the dose escalation phase, affecting a substantial proportion of users