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Methods: Cytotoxicity assays with ferroptosis-sensitive A673 cells transfected to express P-gp or ABCG2 were used to determine the ability of the transporters to confer resistance to FINs

Acknowledgements We thank FigDraw (www.figdraw.com) for creating the model images and granting us copyright ownership

2.2 Absorption and metabolism Once synthesized in the colon, UA can be absorbed through intestinal epithelial cells due to its lipophilic nature, subsequently entering the circulatory system via enterohepatic circulation

of Sheffield, Sheffield, UK, 10 Mary McKillop Institute for Health Research, Australian Catholic Univ., Melbourne, Australia Objective : FRAX models are frequently requested for countries with little or no data on the incidence of hip fracture