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This hyper ECD motion was propagated to the receptor TMD, with motions within TMs 3 and 7, creating a wider TM pocket that also influences the positioning of the N-terminus of the Cagri peptide (Fig

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This progression delineates a developmental pathway in iHLOs, transitioning from epithelial-centric populations to a more diverse composition including mesenchymal cell types by Day 45 (Fig