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Figure 2 Exposure to cagrilintide reduced body weight loss and combination treatment of cagrilintide and semaglutide partially amplified semaglutides association with body weight loss in the DIO rat model

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[15] Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full activity of many enzymes, such as nitric oxide synthase, protein phosphatases, and adenylate kinase, but calcium activates these enzymes in allosteric regulation, often binding to these enzymes in a complex with calmodulin