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Theophylline was not shown to be teratogenic in CD-1 mice at oral doses up to 400 mg/kg, approximately 2.0 times the human dose on a mg/m2 basis or in CD-1 rats at oral doses up to 260 mg/kg, approximately 3.0 times the recommended human dose on a mg/m2 basis

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Overview of ferroptosis Mechanism of ferroptosis Dysfunction iron metabolism and oxidation of lipids Many biochemical and metabolic activities rely on Fe 2+ , including energy metabolism, oxygen transport, and the cellular mitochondrial synthesis of iron-sulfur proteins

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