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2 The main sources of cellular ROS are mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and peroxisomes containing xanthine oxidase and the inducible form of nitric oxide synthase, which produce superoxide anion and nitric oxide, respectively

In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo , and explore the recent potential applications of basic science discoveries in the clinical setting

Although it is effective in targeting cancer cells, it can alter many other tissues like CNS and GI tissue (Bai et al., 2021)

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