is methoxytrate inhibit glutathione rduction Thermally-responsive and reduced glutathione-sensitive folate-targeted nanocarrier based on alginate and pluronic F127 for on-demand release of methotrexate Methotrexate is a folate antagonist

Methotrexate is a folate antagonist that inhibits DNA synthesis by blocking dihydrofolate reductase (DHFR). It is commonly used for rheumatoid arthritis, psoriasis, ectopic pregnancy, and certain cancers. Important adverse effects include hepatotoxicity Methotrexate mechanism in treatment of rheumatoid arthritis ScienceDirect Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Molecular action of methotrexate in inflammatory diseases Arthritis Research & Therapy Springer Nature Link

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