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Investigating how glutamine metabolism adapts to the constantly changing TME clues, such as hypoxia, acidosis, and nutrient deprivation, provides crucial insights into understanding immune cell function and resistance mechanisms [222, 223]

Another type of biomimetic alternative composed of cell-membrane-derived nanoagents has attracted extensive attention in the field of retinal disease treatment [74]

800 Sodium dichloroacetate inhibits accelerated lactate production in mtDNA deletion mice, ameliorates chronic lactic acidosis, improves mitochondrial biogenesis, restores respiratory function, and extends lifespan