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Blood samples are collected at time intervals of 0.5, 1, 2, 4, 6, 8, 10, 12 and 24 hrs and the content of GHK-Cu was estimated

Multiple organ protection models PLoS ONE Safety Data Safety Profile from Research Preclinical Safety Summary Toxicity (in vitro)None at research doses Dermal applicationExtensively safety-tested Cu deliveryPhysiological levels 50+ year researchNo serious concerns Regulatory & Risk Considerations FDA statusNot approved therapeutically Injectable human dataVery limited Copper overloadTheoretical at high doses Long-term systemicNot studied GHK-Cu has an excellent dermatological safety record in topical applications

2) with and without further stress stimuli, an effect attenuated by PKC inhibitors [154, 155]

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