[ref] Not only is B6 important in dopamine production, but it is also important in the creation of glutathione (an antioxidant) in the brain.[ref] Parkinsons patients on L-DOPA also often have low or deficient B6 levels.[ref] Related article : Parkinsons disease and genetic susceptibility Chronic inflammation: Inflammatory conditions, including rheumatoid arthritis, IBD, diabetes, cancer, and deep vein thrombosis, are all associated with low vitamin B6 levels.[ref] While inflammatory conditions are linked to low vitamin B6 levels, it may be (at least partly) because systemic inflammation decreases the bodys P5P levels, and dietary intake isnt sufficient to meet the increased need.[ref] Related article: Chronic inflammation and personalized solutions Asthma and COPD: A recent study showed that higher vitamin B6 intake correlates with higher FEV1 levels (lung function test) in CoPD
It plays a vital role in tissue repair, new blood vessel formation, and reducing inflammationmaking it a favorite for recovery and repair
Why Glutathione Levels Decline Your bodys natural glutathione production can decline due to: Stress and lack of sleep Alcohol or smoking Pollution and UV exposure Aging and poor nutrition Excessive toxin buildup When levels fall, you may experience fatigue, dull skin, low immunity, and sluggish metabolism
As previously noted, ROS activate the NFKB signalling pathway [17, 25]
