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Molz and Schroder, 2017

Agents used for the treatment of refractory atopic dermatitis: dupilumab (a subcutaneous injectable interleukin [IL]-4 and IL-13 receptor-alpha antagonist for treatment in patients aged 6 months with moderate-to-severe atopic dermatitis not controlled by topical prescription therapies) methotrexate azathioprine mycophenolate mofetil cyclosporine JAK inhibitors See Figure1: Summary of the Recommendations for Atopic Dermatitis Therapeutic Management for Pediatric Providers for a diagnostic and treatment model based on treatment guidelines for primary care providers

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Study design and methods used Included studies comprised of non-randomised experimental studies (Holmay et al