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In addition, ERK1/2 plays a critical role in regulation of the polyphenol chlorogenic acid-derived Nrf2 transcriptional activation

The differences in anti-inflammatory properties between CuZnHis(L) and CuZnHis(D) assemblies are mainly attributed to the influence of chirality on cells, with the primary reason being the reduction in immunogenicity caused by the stealth-like effect of the D-type structure 52,53