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Glossary AP-1 Activator Protein 1 ARDS Acute respiratory distress syndrome ARE Antioxidant response element ART Artesunate ASC Apoptosis-associated speck-like protein containing a CARD BALB/c A common laboratory mouse strain Bcl-2 B-cell lymphoma 2 BEAS-2B Bronchial Epithelial Cells Cov Coronavirus COVID-19 Coronavirus Disease 2019 CXCL C-X-C Motif Chemokine Ligand Cy-3-G Cyanidin-3-glucoside DNA Deoxyribonucleic Acid ERK Extracellular signal-regulated kinase GSP Grape seed proanthocyanidins H1N1 Hemagglutinin Type 1 and Neuraminidase Type 1 Influenza A Virus HO-1 Heme Oxygenase-1 IAV Influenza A Virus IKK IB kinase IL-6 Interleukin-6 IRF3 Interferon Regulatory Factor 3 IB Inhibitor of kappa B J774A.1 A murine macrophage cell line JUK C-Jun N-terminal Kinase signaling pathway Keap1 Kelch-like ECH-associated protein 1 MAPK Mitogen-Activated Protein Kinase MDCK Madin-Darby Canine Kidney cells mtDNA Mitochondrial DNA mTOR Mechanistic target of rapamycin mtROS Mitochondrial ROS NADPH Reduced Nicotinamide Adenine Dinucleotide Phosphate NF-B Nuclear Factor kappa-light-chain-enhancer of activated B cells NLRP3 NOD-like receptor family pyrin domain containing 3 NOD1 NAD(P)H Quinone Dehydrogenase 1 Nrf2 Nuclear factor erythroid 2related factor 2 P38 P38 Mitogen-Activated Protein Kinase p65 RelA (part of NF-B) PA Patchouli alcohol PAMPs Pathogen-associated molecular patterns PI3K/Akt Phosphoinositide 3-kinase/Protein Kinase B Pn-3-G Peonidin-3-glucoside RIG Retinoic acid-Inducible Gene RNA Ribonucleic Acid RNS Reactive nitrogen species ROS reactive oxygen species RSV Respiratory syncytial virus SARS Severe Acute Respiratory Syndrome TCM Traditional Chinese Medicine TF2b Theaflavin-3-gallate THP-1 Human monocytic leukemia cell line TLRs Toll-Like Receptors TNF- Tumor necrosis factor-alpha References 1 ArjsriP.SrisawadK.MapoungS.SemmarathW.ThippraphanP.UmsumarngS.et al (2022)

Third-party Certificate of Analysis with HPLC-MS testing Purity greater than 98 percent, preferably 99 percent or higher Endotoxin testing below safe thresholds Clear documentation of peptide sequence and synthesis method Established vendor reputation with verified reviews Appropriate storage and shipping conditions maintained Sourcing Quality Peptides in Canada For Canadian researchers and individuals, sourcing presents unique considerations compared to the American market