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I can tell you that personally, I was a teary, emotional, hair-losing mess when my ferritin was at 16 ng/mL

Improvement in Metabolic Regulation: United States Studies suggest it may improve overall metabolic function

In case of poor results with methylfolate, either mega doses of methlfolate should be given (up to 15 mg were used in studies) to provide sufficient methyl groups or SAM can be given directly