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a therapeutically relevant composition can alleviate a disease or disorder, or a symptom of a disease or disorder when administered at an appropriate dose

We also note, as discussed in section II.C.1.b of this proposed rule, using the December 2022 update of the FY 2022 MedPAR file, we analyzed how applying the NonCC subgroup criteria to all MS-DRGs currently split into three severity levels would affect the MS-DRG structure beginning in FY 2024

As the pqsR strain lacks the ability to produce PQS, which is mostly extracellularly secreted by P