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That is, there is a threshold for intracellular ROS, and when a large accumulation of ROS exceeds the threshold and cannot be neutralized by the antioxidant defence system, it leads to OS and thus cell death

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AGEs are likely responsible for damage to eyes, kidneys, nerves and small blood vessels in diabetes ( Cumin contains several components that reduce AGEs, at least in test-tube studies ( While these studies tested the effects of concentrated cumin supplements, routinely using cumin as a seasoning may help control blood sugar in diabetes ( It is not yet clear what is responsible for these effects, or how much cumin is needed to cause benefits

The pathology topic that is most frequently mentioned in the summaries of the publications on Flavonoids (Table 1, second column) is Alzheimer, followed by Neurodegenerative, Parkinson, Neuroinflammation and Depression