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also high levels of oxidative stress biomarkers and evidence of impaired methylation (high uridine)

and Long, J.A., "Control of Arabidopsis apical-basal embryo polarity by two antagonistic transcription factor families", Nature 464 (7287): 423-426 (2010)

Nat Rev Drug Discov 10 , 453471 (2011)

These findings suggest that glutamate/GABA imbalance, particularly within the corticostriatal pathway, may serve as a key pathophysiological mechanism and potential biomarker in SHANK3-associated ASD