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[DOI] [PubMed] [Google Scholar] 101.Ferrara G., Filosa A., Mariani M.P., Fasanella L

2021;118:e2114828118

Flentjar et al., 2002

When subjected to hindlimb ischemia, Per2 mutant mice presented decreased blood flow and developed autoamputation in the distal limb, indicating that Per2 deficiency could significantly impair endothelial cell function and accelerate vascular senescence, thus leading to endothelial dysfunction [109]