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A number of small human casecontrol studies have found lower ergothioneine levels in older adults with mild cognitive impairment (Reference Cheah, Feng and Tang75) , dementia (Reference Teruya, Chen and Kondoh76) and Parkinsons disease (Reference Hatano, Saiki and Okuzumi77) , in comparison with age-matched healthy individuals

These functional changes in immune cells not only reflect long-term immune activation but also indicate the loss of immune tolerance, leading to the degradation and senescence of immune cell function, thereby exacerbating systemic inflammation

Levels of GSH and GSSG in livers of mice in Figure 2A and Supplemental Figure 1, C and D were measured using Glutathione Assay Kit (Cayman Chemical, 703002)

Against Gamma RadiationInduced Immunosupression and Oxidative Stress in Mice