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While biotin deficiency is relatively uncommon, individuals with certain metabolic conditions, those taking long-term medications such as anticonvulsants, or patients with poor nutritional absorption may benefit from intramuscular administration

doi: 10.3389/fphar.2020.564108 [DOI] [PMC free article] [PubMed] [Google Scholar] 55.Mijit M, Caracciolo V, Melillo A, Amicarelli F, Giordano A

Mannitol, with a cross-sectional hydrated diameter of 6.5 is a small solute that is used as a marker of total intestinal surface area available for absorption, whereas lactulose (with a larger cross-sectional diameter of 9.5 ) is used to assess the paracellular permeability through the tight junctions normalized to the total available intestinal surface [32], with results expressed as a ratio of the permeability of mannitol to lactulose