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K.SodhiM.MohantyA

Kinetics, pharmacokinetics, and regulation of lcarnitine and acetyllcarnitine metabolism

doi: 10.1177/0960327120937329 129 AhmedZAAbtarANOthmanHHAzizTA

Laboratory Investigations Level 1: Renal function, LFT, Proteinuria, Complete blood count, troponin, NT-Pro BNP, Ferritin, Iron, Calcium, Phosphate, Thyroid hormone levels, serum free light chain assay, and urine/serum protein immunofixation (only in case of suspected RCM)Class IC [] Level 2: Viral serology, organ-specific and non-organ-specific investigations, lactic acid, myoglobin, carnitine profile, alpha-galactosidase, thiamine, serum ACE, PTH, free fatty acidsClass II [] Holter: Ventricular tachycardias, nonsustained VTs, heart blocks, atrial arrhythmias MRI: Class I [] contrast CMR during the initial evaluation, ClassIIa [] during monitoring for disease progression or risk stratification for SCD, to assess for therapeutic response in cardiac amyloidosis, hemochromatosis, Anderson Fabry disease, sarcoid, and other inflammatory cardiomyopathies, in family screening genotype positive-phenotype negative to aid early detection and diagnosis