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468 Generalised astrocytic atrophy is also characteristic for alcoholism, in which astrocytes display loss of function, such as for example reduction in synthesis and secretion of thrombospondins

While the factors underlying brain health and longevity discussed below are not exhaustive, they represent what appear to be the most quantifiable and targetable factors underlying neurodegenerative processes along the MCI-ADRD continuum

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200 Promoting ferroptosis using GPX4 inhibitors The essential antioxidant enzyme GPX4 is not only responsible for maintaining redox homeostasis, but is also recognized as the ferroptosis gatekeeper by transforming lipid ROS into lipid alcohols