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10.1097/CRD.0000000000000021 71

Our previous study using intestine-specific Zip14 KO (IKO) mice revealed that intestinal ZIP14 mediates basolateral uptake of Mn from the bloodstream into enterocytes, contributing to Mn excretion into the intestinal lumen ( 54 Mn was administered subcutaneously, intestinal radioactivity was significantly lower in IKO mice compared to controls, indicating impaired basolateral-to-apical Mn transport

Dissecting acute drug-induced hepatotoxicity and therapeutic responses of steatotic liver disease using primary mouse liver and blood cells in a Liver-On-A-Chip model

Traditional PD and AD cellular models based on immortalized cells and primary neurons as well as animal models based on neurotoxin-induced lesion and viral-mediated transgene overexpression are well characterized, widely accepted, and provide relatively straightforward methods to study disease mechanisms and potential therapeutics