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There are reports on the efficacy of sumatriptan in abdominal migraine, a disorder classified in the childhood periodic syndrome subgroup.103,104 Although the mechanisms that cause CVS are not well-defined, there is a clear clinical, familial, therapeutic, and probably pathogenic, parallelism with migraines.69 In a study carried out on a pediatric population, greater treatment efficacy was shown with injectable sumatriptan, compared with intranasal administration

408 Metformin can reduce the SASP by enhancing autophagy and mitophagy and improve the aging of VSMCs and auditory cells

[0393] Examples of certain preferred chelators include unsubstituted or, substituted 2-iminothiolanes and 2-iminothiacyclohexanes, in particular 2-imino-4- mercaptomethylthiolane

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