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This approach has prevented many investigations from dying during the interview process, as do many others that follow a standard approach

Most rodent studies used: 10 micrograms/kg 100 micrograms/kg Administration routes varied by study: Intraperitoneal injection Subcutaneous injection Oral administration in drinking water Example reference: Sikiric et al., 2018 These dosages reflect controlled laboratory conditions and are not generalised outside experimental models

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Only 4.2% discontinued due to side effects after week 24, indicating symptoms become manageable or resolve for the vast majority who continue treatment