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Description

carbazomycin C

Currently, generally recognized is the multiple hit theory, which uses insulin resistance (IR) and obesity the first hit to increase free fatty acids (FFAs) and make the liver more susceptible to hepatotoxic injury

Wang X, Yang B, Yin J, Wei W, Chen JDZ

By the analogy of -glucuronidase linkers, the cleavage mechanism involves the hydrolysis of the -galactosidase moiety, which confers hydrophilicity to the chemical precursor