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Cas9, guided by sgRNAs targeting Acsl4 (5-TGAAATGCAGCCAAATGGAA-3) or Fsp1 (5-TGCACGTGGTGATCGTGGGC-3) [44], mediated cleavage of these genes

This indicates that cells, and specifically mitochondria, that suffer from deuterium overload would be more susceptible to oxidative stress mediated by H 2 O 2