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GHK is a naturally occurring human tripeptide first isolated by Loren Pickart in the early 1970s from human plasma

As reported in Table 1, among the analyzed tumor types, CRC shows the highest number of preclinical studies on DNA methylation ( N = 24), including 16 diagnostic and eight prognostic studies

pH-sensitive targets The tumor microenvironment and intracellular compartments like endosomes and lysosomes often exhibit a lower pH, which can be exploited by pH-sensitive nanocomposites for targeted drug release [136]